How Generative AI Will Make Drug Discovery Ultra-Fast

According to reports, 90 percent of all drug possibilities fail. The few that succeed take an average of 10 years to reach the market and cost from $2.5 billion to $12 billion to get there. The majority of this overall cost and time is attributed to the drug discovery phase needing the synthetization of thousands of molecules to generate a single pre-clinical lead candidate. Hence, researchers are searching for ways to leverage artificial intelligence-based models to expedite this discovery phase at a significantly lower cost. Read on to know more.

Deep generative models, like variationally autoencoders and generative adversarial networks, are considered promising for the computational creation of novel molecules due to their results in the virtual synthesis of images, text, speech, and image captions. Virtual creation of new and optimal lead candidates needs exploring and performing a multi-objective optimization in large chemical space, as the model requires assessment and balance between critical factors like drug activity, stability, selectivity, toxicity, ease of synthesis, etc.

Such multi-objective optimization is managed using either conditional generative models or optimization ways like Bayesian optimization.

Generating new and optimal antimicrobial peptides by learning from a limited repository of known AMP sequences is a challenging task. This research is critical, given that AMPs are viewed as a drug of last resort against antimicrobial resistance, one of the major threats to global health, food security, and development. It is thought that bacterial co-infections and widespread antibiotic use could further antibiotic fuel resistance worldwide.

It is exciting to see deep learning and other techniques being used to pinpoint drug discovery in a matter of days. In particular, exploiting large, publicly-available data to accelerate this process can give huge benefits for a reduced cost. The data-driven method will give better and faster results than the legacy methods, leading to faster drug discovery and safer, more reliable outcomes than clinical trials on their own. While it’s unlikely that AI will replace the present methods overnight, it’s obvious that organizations that add AI to their methods will rapidly replace those who do not.

The life science analytics sector is developing every day with the help of AI, or ML-driven technologies, and the enhancing healthcare data is expected to increase more in the future.

The new databases are rising from digital channels, patient claims, and electronic medical records (EMRs). The stakeholders’ preferences are also developing as the pharma sales reps are finding healthcare physicians (HCPs) more challenging to reach.

According to market researchers, most HCPs will control the in-person sales engagement, opening various opportunities for digital and connected health messaging.

The patients are becoming more digitally connected with the help of implanted health devices and wearables and being unprotected to direct-to-consumer promotions (DTC) like TV Ads, digital ads, and many more. Pharma marketing and brand leaders challenge traditional engagement methods and increase them with consistent, prompt, and relevant messaging with practical and preferred channels.

Pharma marketing strategies have become more proactive than reactive by applying predictive intelligence in the entire analytics infrastructure.

The marketing and brand leaders are cautiously evaluating the likelihood of campaigns to accomplish success and tailor them to best suit the parameters driving performance. It is one of the primary reasons organizations across the globe are pulling up investment in the sector of predive intelligence.

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